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In that study, women with more than nine years of estrogen use had a 70% greater relative risk of breast cancer than controls.

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Palmer JR, Rosenberg L, Clarke EA, Miller DR, Shapiro S "Breast cancer risk after estrogen replacement therapy: results from the Toronto Breast Cancer Study.

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In some cases, this was bleeding related to endometrial carcinoma.

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It is also used for estrogen replacement therapy after failure of the ovaries and to relieve the symptoms of breast cancer.

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Psychiatric side effects have included case reports of rapid mood cycling in patients with severe depression.

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Follow-up to the Nurses' Health Study of 1992 concluded, however, that there is an increased risk of breast cancer in women taking estrogen replacement therapy and that the risk is not reduced by concurrent use of progestins.

Estradiol is the only estrogen available in patch form, however, there are many prescription estrogens that contains estradiol, estrone, estriol or their synthetic (or equine in case of Premarin) equivalents in pill, gel, cream, subcutaneous implant, virginal suppository, or virginal ring forms.

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