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In spinal tuberculosis, there is involvement of more than one vertebra because its segmental arteries bifurcate to supply two adjacent vertebrae.

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At the end of this phase, 182 patients emerged eligible to participate in the randomization phase, during which they were allocated to lamotrigine or placebo monotherapy for 6 months, using flexible lamotrigine dosing from 100 to 500 mg per day.

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We review in detail the development of this assay, its evaluation within the laboratory, its utility among adult and pediatric TB suspects, its use as a screening tool for HIV-associated TB and studies of its implementation at the district and sub-district levels in resource-limited settings.

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