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Misoprostol for treatment of incomplete abortion has been well documented in women presenting with uterine size less than or equal to a pregnancy at 12 weeks since last menstrual period ( LMP).

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The dosages differ depending on many variables which include but are not limited to the following: the number of weeks pregnant the patient is, allergies to medications used to terminate pregnancies, route that the medication is given, what the physician is comfortable in giving and what his experience allows, along with the height and weight of the pregnant woman.

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Forty-two nonpregnant women aged 35-77 years were randomized to a prospective, double-blind study to receive either 400 microg oral misoprostol or placebo 3 hours before office endometrial biopsy.

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Providers need to account for the amount of time needed for counseling women about medical abortion, which generally takes more time than counseling about surgical abortion because women need to know how to take misoprostol and what to expect thereafter.

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Misoprostol works by binding to prostaglandin receptors on the uterus which causes the uterus to contract and expel the fetus and gestational tissue.

Since most NSAIDs are extensively bound to plasma proteins, they may displace other drugs from binding sites or may themselves be displaced by other agents.

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To avoid any complications when taking Misoprostol to reduce gastric ulcer risk, make sure that you are not pregnant within 14 days before you start the treatment, is using effective birth control to avoid getting pregnant, have received oral and written precautions and warnings about the risks of using Misoprostol by women of childbearing age and starting treatment only a few days after a normal menstrual period.

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There also can be similar serious side effects from these drugs.

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Health care providers should explain the procedure, answer questions, provide women with the approved Medication Guide, and review and sign a with the patient before giving these medications to cause abortion.

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